Opioids in Older Adults: Managing Falls, Delirium, and Safe Dose Adjustments

Opioids in Older Adults: Managing Falls, Delirium, and Safe Dose Adjustments

Opioid Fall Risk Assessment Tool

Assess Fall Risk for Older Adults on Opioids

This tool helps identify if an older adult taking opioids is at risk for falls based on STOPPFall criteria. Use this to guide medication reviews and safety planning.

Fall Risk Assessment Results

Note: This tool is based on STOPPFall criteria and should be used as part of a comprehensive clinical assessment. Always consult with a healthcare provider for personalized advice.

Older adults are being prescribed opioids more than ever-but the risks are higher than most people realize. While these drugs can ease pain, they also increase the chance of falls, confusion, and even death in people over 65. The body changes with age: kidneys and liver don’t process drugs as quickly, body fat increases, muscle mass drops, and the brain becomes more sensitive to sedatives. What’s safe for a 40-year-old can be dangerous for a 75-year-old. Yet many doctors still use the same dosing rules across all ages. This mismatch is putting older adults at serious risk.

Why Opioids Are Riskier for Older Adults

It’s not just about taking more pills. The way older bodies handle opioids is fundamentally different. By age 70, kidney function drops by about 50% compared to age 30. The liver slows down too, meaning opioids stay in the system longer. This leads to drug buildup, even at normal doses. Add to that increased body fat and reduced water content, and the drug spreads differently-lingering in fatty tissues and hitting the brain harder.

Even weak opioids like tramadol can cause hyponatremia-a drop in blood sodium-that leads to dizziness, confusion, and nausea. These symptoms are often mistaken for aging or dementia. In reality, they’re drug side effects. And when opioids are mixed with other medications-like benzodiazepines, antidepressants, or blood pressure pills-the risk multiplies. Many seniors take five or more prescriptions daily, and drug interactions are rarely reviewed thoroughly.

Falls: A Silent Epidemic

Falls are the leading cause of injury-related death in older adults. And opioids are a major contributor. Studies show that seniors on opioids are 30% to 50% more likely to fall than those not taking them. Why? Three main reasons: sedation, dizziness from low blood pressure when standing, and poor coordination.

One study of 2,341 adults over 60 found that current opioid users had a 6% fracture rate over 33 months, compared to 4% in non-users. That’s a 28% higher chance of breaking a bone-even if the difference wasn’t statistically significant, the trend is clear. Tramadol, often seen as "safer," has been linked to falls because of its effect on sodium levels. When combined with diuretics or SSRIs, the risk spikes even higher.

It’s not just about slipping on a wet floor. Opioids make people slower to react, blur vision slightly, and dull awareness. A simple turn to reach for a glass can become a fall. And once a fall happens, recovery is harder. Hip fractures in seniors often lead to long-term disability, nursing home placement, or death.

Delirium: Confusion You Can’t Ignore

Delirium-sudden, severe confusion-is common in older adults on opioids. It’s often misdiagnosed as dementia or depression. But unlike dementia, delirium comes on fast, fluctuates during the day, and can be reversed if the trigger is removed.

A landmark 2023 study tracked 75,471 Danes over 65 with dementia. Those who started opioids had an elevenfold higher risk of dying in the first two weeks. That’s not a small increase. That’s a red flag. The researchers found that even short-term opioid use in this group triggered rapid cognitive decline, increased agitation, and respiratory depression. Many doctors didn’t realize how quickly things could go wrong.

Delirium isn’t just scary-it’s deadly. It leads to longer hospital stays, higher rates of institutionalization, and a 30% increased chance of death within a year. Yet it’s still under-recognized. Families assume their loved one is just "getting worse" with age. Clinicians assume it’s Alzheimer’s. But if the person started opioids recently, that’s the first thing to check.

Dose Adjustments: Start Low, Go Slow

There’s no one-size-fits-all dose for older adults. The rule is simple: start low, go slow. Most guidelines recommend beginning with 25% to 50% of the dose you’d give a younger adult. For example, if 10 mg of oxycodone twice daily is standard for a 50-year-old, start with 2.5 to 5 mg for a 75-year-old.

Wait at least 3 to 5 days before increasing the dose. Monitor for drowsiness, unsteadiness, slurred speech, or forgetfulness. If any of these show up, don’t push the dose higher-cut it back. Many doctors don’t do this. They see pain and assume more medicine is better. But in older adults, the line between relief and harm is thin.

Use tools like START/STOPP criteria to guide decisions. STOPP (Screening Tool of Older Person’s Prescriptions) specifically flags opioids as potentially inappropriate in seniors with a history of falls, cognitive issues, or multiple medications. It’s not about denying pain relief-it’s about avoiding unnecessary risk.

A doctor and older woman reviewing medications at a kitchen table, with safer alternatives shown as icons.

The STOPPFall Tool: A Practical Guide for Clinicians

The STOPPFall tool was created by geriatric experts to help doctors decide when to stop or reduce opioids in patients at risk of falling. It’s not a checklist-it’s a conversation starter. It asks questions like: Has the patient fallen in the past year? Are they on more than three sedating medications? Do they have balance problems or dementia?

If the answer is yes to several of these, the tool recommends a gradual taper. It doesn’t say "stop now." It says: "Let’s reduce slowly, watch for withdrawal, and replace with non-drug options." This tool is now being used in clinics across Europe and the U.S. because it works.

Deprescribing isn’t failure. It’s good medicine. Many seniors don’t need opioids long-term. Their pain improves with physical therapy, heat, or nerve blocks. But they’re afraid to stop because they think they’ll be in agony. That’s why trust matters. If a doctor explains why reducing opioids will help them stay independent and safe, patients are more likely to agree.

Why Patients and Doctors Don’t Talk About the Risks

There’s a big gap between what doctors worry about and what patients worry about. Doctors fear falls, confusion, and overdose. Patients fear addiction and being labeled as "drug seekers." Many older adults don’t even know opioids can cause physical dependence in just a few days. They think addiction only happens to people who abuse drugs.

A JAMA study found nearly half of primary care doctors felt unprepared to help patients taper off opioids. They didn’t know how to talk about it without sounding judgmental. Patients, meanwhile, often keep taking opioids because they don’t want to admit they’re struggling. They don’t want to be seen as weak or difficult.

One woman in her 70s told her doctor she’d been taking hydrocodone for 8 years. When asked why, she said, "I don’t want to be in pain. I still want to walk my dog." She didn’t know the drug was making her dizzy, forgetful, and more likely to fall. Her doctor hadn’t asked about side effects in years. That’s the norm, not the exception.

Non-Opioid Alternatives That Work

There are better ways to manage pain in older adults-and they’re safer. Physical therapy improves mobility and reduces pain better than pills for many conditions like arthritis and back pain. Heat wraps, TENS units, and acupuncture have strong evidence for chronic pain. Cognitive behavioral therapy helps people cope with pain without drugs.

Topical NSAIDs like diclofenac gel work well for joint pain and don’t flood the body with medication. Acetaminophen (in low doses) is still a first-line option, though liver function must be checked. For nerve pain, gabapentin or pregabalin can be used-but even these need dose adjustments in seniors.

And don’t underestimate the power of social support. Loneliness worsens pain perception. Group exercise, music therapy, and even pet therapy can reduce pain and improve mood without a single pill.

A senior walking happily in a garden as opioid pills turn into butterflies, surrounded by therapy symbols.

The Bigger Picture: Overprescribing and Its Legacy

Between 2005 and 2014, emergency visits for opioid problems in older adults jumped 112%. Inpatient stays rose 85%. That’s not just a trend-it’s a crisis. And it didn’t happen overnight. For years, opioids were seen as the go-to solution for chronic pain. Doctors were pressured to treat pain aggressively. Patients were told to "take what you need." Now we know better. But the damage is done. Millions of older adults are still on long-term opioids. Many don’t even remember why they started. And stopping suddenly can cause withdrawal-sweating, nausea, anxiety, insomnia. That’s why tapering must be slow and supported.

The CDC and FDA now warn against long-term opioid use in seniors. But guidelines aren’t enough. Doctors need training. Families need education. And patients need someone to listen-not just prescribe.

What Families Can Do

If you have an older relative on opioids, ask these questions:

  1. Why was this drug prescribed? Is the pain still a problem?
  2. Have side effects like dizziness or confusion been checked?
  3. Is there a plan to reduce the dose over time?
  4. Are non-drug options being tried?

Bring a list of all medications to every appointment. Write down any falls, memory lapses, or changes in behavior. Don’t assume the doctor knows. Many don’t ask unless you bring it up.

And remember: reducing opioids doesn’t mean giving up on comfort. It means choosing safety over convenience. It means helping your loved one stay strong, steady, and independent.

Are opioids ever safe for older adults?

Yes-but only in specific cases and with extreme caution. Opioids may be appropriate for short-term use after surgery or for end-of-life pain. For chronic pain, they should be a last resort. If used, start at the lowest possible dose, monitor closely for side effects, and plan to reduce or stop within weeks, not years.

Can opioids cause dementia?

Opioids don’t cause dementia, but they can trigger delirium-a sudden, reversible confusion that mimics dementia. In people who already have early dementia, opioids can make symptoms much worse. Long-term use may also accelerate cognitive decline by reducing brain activity and increasing inflammation. The 2023 Danish study showed a sharp rise in death risk within two weeks of starting opioids in dementia patients.

How do I know if my parent is dependent on opioids?

Physical dependence means the body adapts to the drug and withdrawal symptoms appear if it’s stopped. Signs include increased pain when the dose wears off, anxiety, sweating, nausea, or insomnia. It’s not addiction-there’s no craving or illegal behavior. But dependence still requires a slow taper under medical supervision. Many seniors develop dependence in as little as 7 to 10 days.

What should I do if my parent fell after starting opioids?

Contact their doctor immediately. Do not stop the medication abruptly. Ask for a medication review, especially for sedating drugs. Request a fall risk assessment. Consider using the STOPPFall tool as a guide. In many cases, reducing or switching the opioid can prevent future falls and restore mobility.

Is it safe to combine opioids with over-the-counter sleep aids?

No. Many OTC sleep aids contain diphenhydramine or doxylamine-both are strong sedatives. When mixed with opioids, they increase drowsiness, dizziness, and breathing problems. This combination has led to fatal overdoses in older adults. Always check with a pharmacist before mixing any medication, even if it’s sold without a prescription.

Next Steps: What to Do Today

If you’re a clinician: Review your older patients on opioids. Use START/STOPP criteria. Talk about deprescribing. Use STOPPFall. Document side effects. Offer alternatives.

If you’re a family member: Make a list of all medications. Note any recent falls or confusion. Ask the doctor: "Is this still necessary?" and "What happens if we stop?" Be patient. Change takes time. But safety is worth it.

If you’re an older adult on opioids: Don’t be afraid to ask questions. Your pain matters-but so does your safety. Tell your doctor if you feel dizzy, forgetful, or unsteady. You’re not being difficult. You’re being smart.

The goal isn’t to eliminate opioids entirely. It’s to use them wisely. For older adults, the safest choice is often the one that doesn’t involve pills at all.